Severe hypoproteinemia caused by sevelamer hydrochloride in a hemodialysis patient

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A randomized trial of JTT-751 versus sevelamer hydrochloride in patients on hemodialysis.

BACKGROUND JTT-751 is a novel phosphate binder containing ferric citrate as the active ingredient. METHODS In this Phase 3, multicenter, randomized, open-label, parallel-group study, we compared the efficacy and safety of JTT-751 and sevelamer hydrochloride in patients undergoing hemodialysis. A total of 230 patients with a serum phosphate ≥1.97 and <3.23 mmol/L were randomized to JTT-751 (do...

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Treatment of hyperphosphatemia with sevelamer hydrochloride in hemodialysis patients: a comparison with calcium acetate.

BACKGROUND Sevelamer hydrochloride is a recently approved calcium- and aluminium-free phosphate binder. A randomized study comparing sevelamer and calcium acetate was performed to assess the control of hyperphosphatemia in hemodialysis patients. METHODS Administration of phosphate binders was discontinued during a two-week washout period. The patients were then randomized to receive sevelamer...

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Effect of Sevelamer Hydrochloride on the Serum Calcitriol Concentration in Hemodialysis Patients

Back ground: There are no published clinical data in hemodialysis (HD) patients with mineral bone disorder (CKD-MBD) regarding the effect of sevelamer hydrochloride on the absorption of the oral calcitriol. Objectives: The aim of the present study was to determine the association of the sevelamer hydrochloride and serum 1-25(OH)2D concentration during oral calcitriol therapy. Methods: This was ...

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Effects of sevelamer hydrochloride and calcium carbonate on renal osteodystrophy in hemodialysis patients.

Disturbances in mineral metabolism play a central role in the development of renal bone disease. In a 54-wk, randomized, open-label study, 119 hemodialysis patients were enrolled to compare the effects of sevelamer hydrochloride and calcium carbonate on bone. Biopsy-proven adynamic bone disease was the most frequent bone abnormality at baseline (59%). Serum phosphorus, calcium, and intact parat...

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Successful Pregnancy in a Chronic Hemodialysis Patient

Pregnancy in end stage renal disease women who are on Hemodialysis has been considered a challenging event for both mother and fetus. Generally, outcomes of pregnancy in patients with end-stage renal disease (ESRD) have been considered to be extremely poor, and pregnancy in this group of patients is rather scarce. The frequency of conception is ranged from 0.3% per year in Belgium to 1.4% per y...

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ژورنال

عنوان ژورنال: Nihon Toseki Igakkai Zasshi

سال: 2007

ISSN: 1883-082X,1340-3451

DOI: 10.4009/jsdt.40.281